TNF-α inhibitor
1049741-03-8
547.6
C32H32F3N3O2 • 2(HCl)
-20°C
SPD 304 hydrochloride is a cell-permeable indoly-chromenone compound that rapidly inactivates TNF-α by non-covalently binding to the TNF-α trimer and promotin sbunit dissociation and preventing TNF-α binding to its receptor (IC50 = 22 μM). Shown to selectively inhibit TNF-α, but not IL-1β-induced IkB-α degradation in HeLa cells (IC50 = 4.6 μM).
0.1 lbs
Research or further manufacturing use only, not for food or drug use.
